An anonymous reader writes "Last year Russian researchers discovered a well-preserved mammoth thigh bone and announced plans to clone a mammoth from the bone marrow within — and they just signed a deal with South Korea's Sooam Biotech Research Foundation to bring the project to fruition. The Sooam scientists plan to implant the nucleus of a woolly mammoth cell into an elephant egg in order to to create a mammoth embryo, which would then be placed in an elephant womb. 'This will be a really tough job,' Soaam reasearcher Hwang In-Sung said, 'but we believe it is possible because our institute is good at cloning animals.'" Not to be confused with a similar mammoth effort at mammoth-cloning at Kyoto University.

New submitter greatgreygreengreasy writes "According to NPR, 'Lawmakers in New York approved a bill that will make the state the first to require DNA samples from almost all convicted criminals. Most states, including New York, already collect DNA samples from felons, according to the National Conference of State Legislatures. What's remarkable about the New York bill is that it would expand the state's database to include DNA from people convicted of almost any crime, even misdemeanors as minor as jumping over a subway turnstile.' Gattaca seems closer than we may have thought. Richard Aborn, one of the bill's backers, said, 'We know from lots of studies and lots of data now that violent criminals very often begin their careers as nonviolent criminals. And the earlier you can get a nonviolent criminal's DNA in the data bank, the higher your chances are of apprehending the right person.'"

First time accepted submitter eternaldoctorwho writes "Research has been underway to produce a coffee bean plant that naturally has no or little caffeine content. Now, it looks like that might become a reality in the near future: Paulo Mazzafera of the University of Campinas in Brazil has come closer than ever with a strain containing 'only 2% of normal caffeine levels.' Coffee, anyone?"

ananyo writes "In another victory for crowdsourcing, gamers playing Phylo have beaten a state-of-the-art program at aligning regions of 521 disease-associated genes form different species. The 'multiple sequence alignment problem' refers to the difficulty of aligning roughly similar sequences of DNA in genes common to many species. DNA sequences that are conserved across species may play an important role in the ultimate function of that particular gene. But with thousands of genomes likely to be sequenced in the next few years, sequence alignment will only become more difficult in future. Researchers now report that players of Phylo have produced roughly 350,000 solutions to various multiple sequence alignment problems, beating the accuracy of alignments from a program in roughly 70% of the sequences they manipulated."

derekmead writes "Forget CFLs, hybrid cars, and organic jeans. Buying our way out of climate change — even if it's green consumption — won't get us far. A new paper (PDF), published in Ethics, Policy, and the Environment by NYU bioethics professor S. Matthew Liao, poses an answer: engineer humans to use less. The general plan laid out by Liao is straightforward, ranging from using pharmacological behavior modification to create an aversion to meat in people, to using gene therapy to create smaller, less resource-intensive children. The philosophical and ethical questions, on the other hand, are absurdly complicated. The Atlantic also has a great interview with Liao, in which he talks about gene therapy and making humans hate the taste of meat."

An anonymous reader sends this excerpt from MIT's Technology Review: "A new blob-like robot described in the journal Advanced Robotics uses springs, feet, 'protoplasm' and a distributed nervous system to move in a manner inspired by the slime mold Physarum polycepharum. ... Researcher Takuya Umedachi of Hiroshima University has been perfecting his blob-bot for years, starting with early prototypes that used springs but lacked an air-filled bladder. ... Umedachi modeled his latest version on the 'true' slime mold, which has been shown to achieve a 'human-like' decision-making capacity through properties emerging from the interactions of its individual spores (abstract). Slime molds appear to have general computational abilities, and you've probably heard that they can solve mazes."

New submitter Guppy writes "A previous story reported widely in the media, and appearing both on Slashdot and XKCD, described a novel cancer treatment, in which a patient's own T-cells were modified using an HIV-derived vector to recognize and kill leukemia cells. In a follow-up publication (PDF), a further development is described which allows for a nearly unlimited choice of target antigens, broadening the types of malignancies potentially treatable with the technique (abstract)."

LilaG writes "Not just a way to transport trains at high speed, magnetic levitation could find use in diagnosing disease. Researchers at Harvard have shown that they can detect proteins in blood using MagLev. The researchers, led by George Whitesides, use levitation to detect a change in the density of porous gel beads that occurs when a protein binds to ligands inside the beads. The lower the bead levitates, the more protein it holds. The method (abstract of paywalled article) could work for detecting disease proteins in people's blood samples in the developing world: The magnets cost only about $5 each, and the device requires no electricity or batteries. Because the beads are visible to the naked eye, researchers can make measurements with a simple ruler with a millimeter scale."

ananyo writes "Bioethicist Glenn McGee has resigned his position as president of ethics and strategic initiatives at the stem-cell firm Celltex Therapeutics in Houston, Texas. Yesterday, Slashdot posted a story that suggested Celltex may have administered unproven treatments to several patients. The move comes at the end of a turbulent three months, which has seen McGee blasted by other bioethicists for working at the controversial stem-cell company while also holding the post of editor-in-chief of the American Journal of Bioethics, the most cited bioethics journal in the world. McGee announced that he had resigned, effective 28 February, on Twitter last night — the move came just two weeks after the 13 February press release by Celltex announcing that he would take the position."

cylonlover writes "A strong and highly selective instant adhesive inspired by the bacterium Streptococcus pyogenes has been developed by Oxford University researchers. S. pyogenes is a common resident of human throats that is normally kept in check by the body's defenses, but when it gets out of control it can cause diseases ranging from strep throat to toxic shock syndrome or flesh-eating disease. By engineering a protein that is central to S. pyogenes' infectious arsenal, the researchers have developed a new superglue that can't be matched for sticking molecules together and not letting go."

ananyo writes "With Texas pouring millions of dollars into developing adult stem-cell treatments, doctors there are already injecting paying customers with unproven preparations, supplied by an ambitious new company. Celltex Therapeutics 'multiplies and banks' stem cells derived from people's abdominal fat and its facility in Sugar Land opened in December 2011 and houses the largest stem-cell bank in the United States. But Nature has uncovered evidence that the company is involved in the clinical use of the cells on US soil, which the FDA has viewed as illegal in other cases."

An anonymous reader writes "Researchers from The University of Nottingham have demonstrated how a species of flatworm overcomes the aging process to be potentially immortal. The discovery, published (abstract; full text PDF) in the Proceedings of the National Academy of Sciences, is part of a project funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council and may shed light on the possibilities of alleviating aging and age-related characteristics in human cells." After finding the gene for telomerase synthesis in the worms, the researchers were able to observe that the worms "...dramatically increase the activity of this gene when they regenerate, allowing stem cells to maintain their telomeres as they divide to replace missing tissues."

sciencehabit writes "Men typically produce working sperm as long as they live, but most textbooks say female mammals are born with all the egg cells, or oocytes, they will ever have. Since 2004, however, reproductive biologist Jonathan Tilly of Massachusetts General Hospital in Boston has challenged that conventional wisdom, arguing that in mice—and perhaps also in humans—there must be an ongoing source of new eggs. Today, Tilly and his colleagues report isolating rare cells in ovarian tissue from adult women that can grow in lab dishes and form immature oocytes. The potential egg stem cells could help scientists devise new ways to help rescue the fertility of women who have to undergo cancer treatments or who suffer from premature menopause."

First time accepted submitter awjourn writes "During his years working in pharma R&D, Tomasz Sablinski was frustrated by the industry's need for secrecy and its utter inability to design patient-friendly drug trials. So he founded Transparency Life Sciences, a company that's developing three drugs based on input from patients and physicians, who log onto the company's site and voice their opinions about how drugs should be designed and tested."

An anonymous reader writes "It was an Ice Age squirrel's treasure chamber, a burrow containing fruit and seeds that had been stuck in the Siberian permafrost for over 30,000 years. From the fruit tissues, a team of Russian scientists managed to resurrect an entire plant in a pioneering experiment that paves the way for the revival of other species. The Silene stenophylla is the oldest plant ever to be regenerated, the researchers said, and it is fertile, producing white flowers and viable seeds. ... 'The squirrels dug the frozen ground to build their burrows, which are about the size of a soccer ball, putting in hay first and then animal fur for a perfect storage chamber,' said Stanislav Gubin, one of the authors of the study, who spent years rummaging through the area for squirrel burrows. 'It's a natural cryobank.'"

someWebGeek writes "From PhysOrg's 'Taking biofuel from forest to highway,' University of British Columbia biofuel expert Jack Saddler says, 'we will become less dependent on fossil fuels and will become more dependent on fuels made from the sugars and chemicals found in plants.' Nothing too new there; the idea of biofuels eventually taking over from petroleum distillates has been around for ages. However, Saddler contends further that 'Similar to an oil refinery that processes crude oil to make thousands of supplementary products like plastics, dyes, paints, etc., the biorefinery would use leftover agricultural and forest material to make many of the same products, but from a sustainable and renewable resource.' I remember my organic chem instructor back in '81 telling us that eventually the textbooks would have to be rewritten. There would be no presumption of fractional distillation of thousands of basic compounds from petroleum, and the teaching emphasis would shift to synthesis from simple hydrocarbons. He noted that we'd all miss 'the good, ole days' when synthetic fibers, plastics, etc. were cheap... or even an economically viable option. I can live without rayon, but, dang, I'm gonna miss polyvinyl chloride!"

Zothecula writes "Oxford Nanopore has been developing a disruptive nanopore-based technology for sequencing DNA, RNA, proteins, and other long-chain molecules since its birth in 2005. The company has just announced that within the next 6-9 months it will bring to market a fast, portable, and disposable protein sequencer that will democratize sequencing by eliminating large capital costs associated with equipment required to enter the field."

ananyo writes "A burger made entirely from lab-grown meat is expected to be unveiled by October this year. But costing in excess of $250,000, it's not going to be flying off supermarket shelves quite yet. The lab meat is produced using adult stem cells, which are then grown on scaffolds in cell-culture media. Because such lab-assembled muscle is weak, it has to be 'bulked up' by exposing to electric shocks. The researchers, based in the Netherlands, had already grown goldfish fillets in 2002, then fried them in breadcrumbs before giving them to an 'odor and sight' panel to assess whether they seemed edible." While I'm not overly enthusiastic about this Dutch attempt at growing burgers, it is a huge step-up from the Japanese effort.

Edsj writes "A spokesman for the World Health Organization announced that an agreement had been reached, after a debate, to keep details secret of the controversial work about the highly pathogenic H5N1 avian flu virus until deeper risk analyses have been carried out. The scientists who made the study, led by Ron Fouchier, still want to release the full paper at some future date for public viewing, but for the time being, the NSABB got what it wanted." The moratorium will be extended "probably for several months."

ananyo writes "DNA origami, a technique for making structures from DNA, has been used to build devices that can seek out and potentially destroy cancer cells. The nanorobots use a similar system to cells in the immune system to engage with receptors on the outside of cells. The barrel-shaped devices, each about 35 nanometers in diameter, contain 12 sites on the inside for attaching payload molecules and two positions on the outside for attaching aptamers, short nucleotide strands with special sequences for recognizing molecules on the target cell (abstract). The aptamers act as clasps: once both have found their target, they spring open the device to release the payload. The researchers tested six combinations of aptamer locks, each of which were designed to target different types of cancer cells in culture. Those designed to hit a leukemia cell could pick that cell out of a mixture of cell types, then release their payload — in this case, an antibody — to stop the cells from growing. The researchers designed the structure of the nanorobots using open-source software, called Cadnano."