ananyo writes "Chemists have turned red blood cells into long lived sensors that could be put back into circulation to monitor the make up of patients' blood in real time. Many patients require monitoring of their blood, such as diabetics. But extracting blood is both invasive and provides only a one-off measurement. At the American Chemical Society meeting in Philadelphia, Xiaole Shao explained how her team has built sensors that may one day allow both non-invasive and long-term monitoring of crucial aspects of blood chemistry. Shao, a chemist at the University of Missouri-Columbia, and her colleagues exploited the fact that near-infrared light will penetrate skin. This means it can trigger florescent molecules that are circulating in the blood, and this florescence can be picked up by an external monitoring device. If the molecule's florescence changes in response to chemical conditions, these changes can also be detected, and you have a sensor. But florescent dyes can be toxic, and they don't last long in the body, as they are quickly filtered out. To avoid the problem, the researchers encapsulated the sensors in red blood cells. The team next plans to inject the sensors into rats."

ananyo writes "Developing oral contraceptives for men has not gone as swiftly as researchers imagined in the early 1970s; they suggested at the time that a 'male pill' was not far off. But researchers now report a new way to make male mice temporarily infertile. Although the treatment is not ready for human use, the method avoids some of the pitfalls of earlier attempts. The technique appears to have a much more specific action than previous methods: it impairs sperm production by blocking a protein called BRDT. This protein was singled out as a potential therapeutic target five years ago because it only occurs in the testes, where it is required for the division of sperm cells. If the approach proves safe in humans, it would be an improvement over hormone-based methods of male contraception, which are not completely effective and cause side effects such as mood swings, acne and a loss of libido (abstract). On the downside, however, the compound 'shrank the mice's testes.'"

ananyo writes "Gene patents have been upheld in a landmark case over two genes associated with hereditary forms of breast and ovarian cancer. The lawsuit against Myriad Genetics, a diagnostic company based in Salt Lake City, Utah, that holds patents on the genes BRCA1 and BRCA2, has bounced from court to court since 2010. In a 2-1 decision today, a federal appeals court reaffirmed their latest decision that genes represent patent-eligible matter. As noted before on Slashdot, the case will have major implications for cancer researchers, patients and drug makers."

sciencehabit writes with this mind-boggling bit from Science Magazine: "When it comes to storing information, hard drives don't hold a candle to DNA. Our genetic code packs billions of gigabytes into a single gram. A mere milligram of the molecule could encode the complete text of every book in the Library of Congress and have plenty of room to spare. All of this has been mostly theoretical—until now. In a new study, researchers stored an entire genetics textbook in less than a picogram of DNA — one trillionth of a gram — an advance that could revolutionize our ability to save data."

lukehopewell1 writes "Australian billionaire Clive Palmer has already floated a plan to rebuild the Titanic to scale and sail it around the world, but now the mining magnate has found a new use for his money: cloning dinosaurs. Palmer reportedly wants to clone a dinosaur and let it loose in one of his resorts in Queensland, Australia. The billionaire has already been in touch with the scientists who helped clone Dolly the sheep to see what it would take to clone a dinosaur from DNA."

ananyo writes "Digestible microchips embedded in drugs may soon tell doctors whether a patient is taking their medications as prescribed. The 'digital pills' are the first ingestible devices approved by the U.S. Food and Drug Administration. The pills contain a sand-particle sized sensor, consisting of a minute silicon chip containing trace amounts of magnesium and copper. When swallowed, it generates a slight voltage in response to digestive juices, which conveys a signal to the surface of a person's skin where a patch then relays the information to a mobile phone belonging to a healthcare-provider. Currently, the FDA, and the analogous regulatory agency in Europe have only approved the device based on studies showing its safety and efficacy when implanted in placebo pills. But Proteus Digital Health, the manufacturer, hopes to have the device approved within other drugs in the near future."

ananyo writes "A court decision on 23 July could help to tame the largely unregulated field of adult stem-cell treatments. The US District Court in Washington DC affirmed the right of the Food and Drug Administration (FDA) to regulate therapies made from a patient's own processed stem cells. The case hinged on whether the court agreed with the FDA that such stem cells are drugs. The judge concurred, upholding an injunction brought by the FDA against Regenerative Sciences, based in Broomfield, Colorado. The FDA had ordered Regenerative Sciences to stop offering 'Regenexx', its stem cell treatment for joint pain, in August 2010. As Slashdot has noted before, they are far from the only company offering unproven stem cell therapies."

An anonymous reader writes "Researchers reporting online on July 26 in Current Biology have for the first time shown that they can control the behavior of monkeys by using pulses of blue light to very specifically activate particular brain cells (abstract). The findings represent a key advance for optogenetics, a state-of-the-art method for making causal connections between brain activity and behavior. Based on the discovery, the researchers say that similar light-based mind control could likely also be made to work in humans for therapeutic ends."

Maximum Prophet writes "If you've ever had your eyes scanned, be sure to install new ones every 90 days. Wired reports on research being released at Black Hat: 'The replica images, they say, can trick commercial iris-recognition systems into believing they’re real images and could help someone thwart identification at border crossings or gain entry to secure facilities protected by biometric systems. The work goes a step beyond previous work on iris-recognition systems. Previously, researchers have been able to create wholly synthetic iris images that had all of the characteristics of real iris images — but weren’t connected to real people. The images were able to trick iris-recognition systems into thinking they were real irises, though they couldn’t be used to impersonate a real person. But this is the first time anyone has essentially reverse-engineered iris codes to create iris images that closely match the eye images of real subjects, creating the possibility of stealing someone’s identity through their iris.'"

ananyo writes "The first competitor has swaggered up to the starting line for a contest that aims to push the limits of genome-sequencing technology. The X Prize Foundation of Playa Vista, California, is offering a US$10 million prize to the first team to accurately sequence the genomes of 100 people aged 100 or older, for $1,000 or less apiece and within 30 days. Ion Torrent, part of Life Technologies of Carlsbad, California, believes that its semiconductor-based technology gives it a shot, and on 23 July it announced that it will compete. The Archon Genomics X Prize competition, to be held in September 2013, is intended to spur technology, boost accuracy and drive down costs — currently $3,000–5,000 per genome. Peter Diamandis, the X Prize Foundation's chief executive, says that the contest will help to establish a standard for a 'medical grade' genome, with the high accuracy needed to diagnose or treat a patient. This time, the X prize Foundation has relaxed the time frame, allowing competitors 30 days — rather than the 10 specified by the 2006 contest — and focused on centenarians, who might carry gene variants promoting longevity. The winning team will be the first to sequence all 100 genomes to 98% completion, with less than one error per million base pairs, and to determine which variants appear on which of the paired chromosomes."

An anonymous reader writes "The inaugural G-Prize contest, conceived and exclusively sponsored by Gen9, was launched to foster creative and innovative approaches for using synthetic DNA libraries to constructively advance industries such as pharmaceuticals, chemicals, biofuels and agriculture. Winners of the inaugural G-Prize will receive a free library of up to 500 GeneBits DNA constructs. Each GeneBits construct is a double-stranded gene fragment from 500 to 1,024 base-pairs in length, with error rates better than 1:2,500."

Diggester writes "While Americans worry every year about getting a flu shot or preventing HIV/AIDS, the deadlier silent killer is actually Hepatitis C, killing over 15,000 people yearly in the U.S. since 2007 — and the numbers continue to increase as the carriers increase in age. While there is no vaccine, there is hope in nanoparticle technology. The breakthrough came from a group of researchers at the University of Florida, creating a 'nanozyme' that eliminates the Hep C 100% of the time; before now, the six-month treatment would only work about half the time. The particles are coated with two biological agents, the identifier and the destroyer; the identifier recognizes the virus and sends the destroyer off to eliminate the mRNA which allows Hep C to replicate." Reader Joiseybill adds a link to coverage in the IEEE Spectrum, and points out that the 100 percent success rate, while encouraging, is so far only in the lab.

ananyo writes "Bioengineers have made an artificial jellyfish using silicone and muscle cells from a rat's heart. The synthetic creature, dubbed a medusoid, looks like a flower with eight petals. When placed in an electric field, it pulses and swims exactly like its living counterpart. The team now plans to build a medusoid using human heart cells. The researchers have filed a patent to use their design, or something similar, as a platform for testing drugs (abstract). 'You've got a heart drug?' says Kit Parker, a biophysicist at Harvard University in Cambridge, Massachusetts, who led the work. 'You let me put it on my jellyfish, and I'll tell you if it can improve the pumping.'" The video that accompanies the text is at once beautiful and creepy.

another random user writes "According to the BBC, 'Europe is on the cusp of approving a gene therapy for the first time, in what would be a landmark moment for the field. ... The European Medicines Agency has recommended a therapy for a rare genetic disease which leaves people unable to properly digest fats. The European Commission will now make the final decision. The idea of gene therapy is simple: if there is a problem with part of a patient's genetic code then replace that part of the code. The reality has not been so easy. In one gene therapy trial a U.S. teenager, Jesse Gelsinger, died, and other patients have developed leukaemia. There no gene therapies available outside of a research lab in Europe or the U.S.' They have considered the use of Glybera to treat lipoprotein lipase deficiency, which leads to fat building up in the blood, abdominal pain and life-threatening pancreatitis (inflammation of the pancreas). 'The therapy uses a virus to infect muscle cells with a working copy of the gene.'"

dstates writes "An industry has grown up around patents guaranteeing exclusive access to testing of mutations in specific genes, but recently the Supreme Court rejected a biotechnology patent saying laws of nature cannot be patented, and threw the issue of patents on genes back to the lower courts. The Court of Appeals is now preparing to hear arguments on whether genes can be patented. The results will have major implications. On the one hand, restricting access to whole regions of the human genome will stifle scientific progress. On the other, companies like Myriad Genetics and Optimal Medicine use the patents to protect years of work invested in research, but this also means preventing other companies from offering diagnostics based on competing faster and lower cost technologies to analyze mutations in these genes."

ananyo writes "With the Olympics due to kick off on 27 July in London, Nature has taken a look at how far science would be able to push human athletic abilities if all restrictions on doping were lifted. The article mentions anabolic steroids (up to 38% increase in strength), IGF-1 (4% increase in sprinting capacity), EPO/blood doping (34% increase in stamina), gene doping and various drugs and supplements, as well as more 'extreme' measures such as surgery and prosthesis. Hugh Herr, a biomechanical engineer at MIT, says performance-enhancing technologies will one day demand an Olympics all their own. But is that time already upon us?"

First time accepted submitter rosy rohangi writes "Biologists at UC San Diego have discovered a chemical that provides a completely new direction and promise for the development of drugs to treat metabolic disorders such as type 2 diabetes – a key concern of public health in the U.S. due to the current obesity epidemic. From the article: '...Scientists have long suspected that diabetes and obesity could be related to problems of the biological clock. Laboratory mice with altered biological clocks, for example, often become obese and develop diabetes. Two years ago, a team led by Steve Kay, dean of the Division of Biological Sciences at UC San Diego, discovered the first biochemical link between the biological clock and diabetes. He found that a key protein, cryptochrome, which regulates the biological clocks of plants, insects and mammals also regulates glucose production in the liver and that changes in levels of this protein could improve the health of diabetic mice.'"

stoilis sends this quote from an article at Science: "Vaccines aren't supposed to cause disease. But that appears to be what's happening on Australian farms. Scientists have found that two virus strains used to vaccinate chickens there may have recombined to form a virus that is sickening and killing the animals 'This shows that recombination of such strains can happen and people need to think about it,' says Glenn Browning, a veterinary microbiologist at the University of Melbourne, Parkville, in Australia and one of the co-authors on the paper."

An anonymous reader writes with news that researchers at the Georgia Institute of Technology have taken a gene from 500-million-year-old bacteria and inserted it into modern E. coli bacteria. They then allowed the bacteria to evolve over the course of a thousand generations to see whether it would resemble its original 'evolutionary trajectory.' From the article: "After achieving the difficult task of placing the ancient gene in the correct chromosomal order and position in place of the modern gene within E. coli, Kaçar produced eight identical bacterial strains and allowed 'ancient life' to re-evolve. This chimeric bacteria composed of both modern and ancient genes survived, but grew about two times slower than its counterpart composed of only modern genes. 'The altered organism wasn’t as healthy or fit as its modern-day version, at least initially,' said Gaucher, 'and this created a perfect scenario that would allow the altered organism to adapt and become more fit as it accumulated mutations with each passing day.' The growth rate eventually increased and, after the first 500 generations, the scientists sequenced the genomes of all eight lineages to determine how the bacteria adapted. Not only did the fitness levels increase to nearly modern-day levels, but also some of the altered lineages actually became healthier than their modern counterpart."

awjourn writes "As the SEC hashes out the final rules for crowdfunding equity investments in startups, one NYC entrepreneur is jumping into an industry that popular crowdfunding sites like Kickstarter won't go anywhere near: health. His company, MedStartr, launched July 11 with six companies seeking to raise money from the crowd for their health products and services. Among them, EndoGoddess, an app diabetics can use to track their blood sugar. Even MedStartr wants to raise funding on MedStartr. But will crowdfunding fly in healthcare, and more importantly, will regulators at the FDA and SEC be on board with it?"