An anonymous reader writes "Scientists successfully reversed diabetes in mice by transplanting mice human stem cells into mice in a discovery that may lead to way to finding a cure for a disease that affects 8.3 percent of the U.S. population. ... In an experiment designed to mimic human clinical conditions, researchers were able to wean diabetic mice off of insulin four months after the rodents were transplanted with human pancreatic stem cells (abstract). [They] were able to recreate the 'feedback loop' that enabled insulin levels to automatically rise or fall based on the rodents' blood glucose levels. Additionally, researchers found that the mice were able to maintain healthy blood sugar levels even after they were fed large quantities of sugar. After several months, researchers removed the transplanted cells from the mice and found that the cells had all the markings of normal insulin-producing pancreatic cells."

ananyo writes "Two anti-clotting compounds already approved for use in humans may have a surprising role in treating radiation sickness. Last year's nuclear accident in Fukushima, Japan renewed anxiety over the lack of treatments for radiation poisoning. It was long thought that the effects of exposure to high doses of radiation were instantaneous and irreversible, leading to destruction of the gut and loss of bone marrow cells, which damages blood-cell production and the immune system. The two compounds are thrombomodulin (Solulin/Recomodulin), currently approved in Japan to prevent thrombosis, and activated protein C (Xigris). Treating mice with either drug post-exposure led to an eightfold increase in key bone marrow cells needed for the production of white blood cells, and improved the survival rates of mice receiving lethal radiation doses by 40–80% (abstract). And yes, the lead author's name really is Geiger."

ananyo writes "A report presented at the 2012 BIO International Convention in Boston, Massachusetts suggests that patents do not stifle progress when they occur at early phases of research, as some have suggested. Over the past decade, increases in patents have been matched by growth in the biotech and pharmaceutical sectors in India, Brazil, Singapore and other countries with emerging economies. The strength of patent rights can be quantified in an index ranging from 0 (no patent rights) to 5 (very strong). Over time, the countries that U.S. biotech and pharmaceutical companies have invested in have moved up the IP barometer, the report (PDF) says."

Peristaltic writes "Scientists at the U.S. Department of Agriculture are trying to determine if an unexpected mutation in a popular GM grass, Tifton 85, is responsible for the sudden deaths of a small herd of cattle in Elgin, Texas three weeks ago. The grass has been used for grazing since 1992 without incident, however after a severe drought last year in Texas, the grass started producing cyanide in sufficient quantities to kill a small herd of cattle in Elgin, Texas. Testing has found the cyanide-producing grass in nearby fields as well." Update: 06/23 22:59 GMT by T : Reader Jon Cousins writes with a correction that means the headline above is inaccurate for including "GM." Tifton 85, he writes, is "absolutely not genetically modified. It's a conventionally bred hybrid."

carmendrahl writes "Why do foods taste good together? Scientists aren't anywhere near figuring it out, but that hasn't stopped one popular idea from spawning a company dedicated to discovering avant-garde new pairings. The idea, called flavor-pairing theory, says that if foods share a key odor molecule, they'll pair well. But some scientists say the idea can't explain all cuisines, and another contends his work with tomato flavor (abstract) shows that flavor pairing is 'a gimmick by a chef who is practicing biology without a license.'"

ananyo writes "Japanese scientists have coaxed stem cells into forming a 5-millimeter-long, three-dimensional tissue that the researchers labelled a liver bud — an early stage of liver development. The bud lacks bile ducts but has blood vessels, and when transplanted into a mouse, was able to metabolize some drugs that human livers metabolize but mouse livers normally cannot. The work is 'the first report demonstrating the creation of a human functional organ with vascular networks from pluripotent stem cells,' the team claims."

Harperdog writes "Laura Kahn has a great article about the long and fascinating history of do-it-yourself research, from Darwin and Mendel to present day. From the article: 'Welcome to the new millennium of do-it-yourself (DIY) biology. Advances in technology in the twenty-first century have enabled anybody, with the desire and the disposable income, to build rather sophisticated laboratories in their own homes. Entire communities have even materialized to promote these efforts -- like the thousands of amateur biologists who contribute to DIYbio.org, a website "dedicated to making biology an accessible pursuit for citizen scientists, amateur biologists and biological engineers."'"

Shipud writes "Sequencing the genome of an organism is not the end of a discovery process; rather, it is a beginning. It's the equivalent of discovering a book whose words (genes) are there, but their meaning is yet unknown. Biocurators are the people who annotate genes — find out what they do — through literature search and the supervised use of computational techniques. A recent study published in PLoS Computational Biology shows that biocurators probably perform no better than fully automated computational methods used to annotate genes. It is not clear whether this is because the software is of high quality, or both curators and software need to improve their performance. The author of this blog post uses the concept of the uncanny valley to explain this recent discovery and what it means to both life science and artificial intelligence."

stillnotelf writes "ScienceInsider is covering a National Institutes of Health advisory committee report that details problems in the U.S. biomedical research workforce. Current policies encourage the training of large numbers of biomedical graduate students, as they are the cheapest labor available, but the research enterprise is not structured to absorb them into full-time scientist positions. The report's varied suggestions include removing graduate student funding from investigator-linked research grants (shifting it to institution-linked training grants instead) and encouraging the hiring of staff scientists as permanent lab members. This would reduce the number of trainees, but increase the proportion of trainees that maintain careers as researchers. ScienceInsider further notes that a National Research Council report 14 years ago noted a similar problem, but never motivated change."

scibri writes "Biotech giant Monsanto is one step closer to losing billions of dollars in revenues from its genetically-modified Roundup Ready soya beans, after the Brazilian Supreme Court ruled the company must repay royalties collected over the past decade. Since GM crops were legalized in 2005, Monsanto has charged Brazilian farmers royalties of 2% on their sales of Roundup Ready soya beans. The company also tests Brazilian soya beans that are sold as non-GM — if they turn out to be Roundup Ready, the company charges the farmers 3%. Farmers challenged this as an unjust tax on their business. In April a regional court ruled against Monsanto, though that ruling has been put on hold pending an appeal. The Supreme Court, meanwhile has said that whatever the final ruling is, it will apply throughout the whole country."

An anonymous reader writes in with a story about a milestone in stem cell medicine. "A ten year old girl became the first person in the world to get a major blood vessel replaced by one grown using her own stem cells. The 10-year-old from Sweden had a blockage of a vein from her liver. The doctors decided to give her a new vein instead of a liver transplant or giving her a vein from her own body, Associated Press reported. The team from University of Gothenburg first took 9 cm vein segment from a dead man and stripped all living cells from it, leaving behind only a protein structure. They later reconstructed the vein by using cells from the girl's own bone marrow. The new graft was then put in the girl's body two weeks later."

ananyo writes "Monkeys infected with Ebola have been cured by a cocktail of three antibodies first administered 24 hours or more after exposure. The result raises hopes that a future treatment could improve the chances of humans surviving the disease caused by the deadly virus, which kills up to 90% of infected people and could potentially be used as a biological weapon. Most treatment regimes tested to date only improve chances of survival if administered within one hour of infection (abstract)."

MrSeb writes "Neuroengineers at MIT have created an implantable fuel cell that generates electricity from the glucose present in the cerebrospinal fluid that flows around your brain and spinal cord. The glucose-powered fuel cell is crafted out of silicon and platinum, using standard semiconductor fabrication processes. The platinum acts as a catalyst, stripping electrons from glucose molecules, similar to how aerobic animal cells (such as our own) strip electrons from glucose with enzymes and oxygen. The glucose fuel cell produces hundreds of microwatts (i.e. tenths of a milliwatt), which is a surprisingly large amount — it comparable to the solar cell on a calculator, for example. This should be more than enough power to drive complex computers — or perhaps more interestingly, trigger clusters of neurons in the brain. In theory, this glucose fuel cell will actually deprive your brain of some energy, though in practice you probably won't notice (or you might find yourself growing hungry sooner)."

ananyo writes "Hungary's Medical Research Council (ETT), which advises the government on health policy, has asked public prosecutors to investigate a genetic-diagnostic company that certified that a member of parliament did not have Roma or Jewish heritage. The MP in question is a member of the far-right Jobbik party, which won 17% of the votes in the general election of April 2010. He apparently requested the certificate from the firm Nagy Gén Diagnostic and Research. The company produced the document in September 2010, a few weeks before local elections. Nagy Gén scanned 18 positions in the MP's genome for variants that it says are characteristic of Roma and Jewish ethnic groups; its report concludes that Roma and Jewish ancestry can be ruled out." Adds ananyo: "The test is of-course nonsense, and notions of 'racial purity' have long been discredited." Just when you think the world is too modern for such things, modernity gets hijacked by flim-flam.

ChromeAeonium writes "Shortly after the events in Rothamsted Research in the UK, where a publicly funded trial of wheat genetically engineered to repel aphids was threatened by activists with destruction and required police protection, another publicly funded experiment involving genetically engineered crops faces possible destruction (original in Italian). The trial, which is being conducted by researchers at the University of Tuscia in Italy on cherries, olives, and kiwis genetically engineered to have traits such as fungal disease resistance, started three decades ago. When field research of GE plants was banned in Italy in 2002, the trial received an extension to avoid being declared illegal, but was denied another in 2008, and following a complaint from the Genetic Rights Foundation, now faces destruction on June 12th, despite appeals from scientists. The researchers claim that the destruction is scientifically unjustifiable (only the male kiwis produce transgenic pollen and their flowers are removed) and wish to gather more information from the long running experiment."

An anonymous reader writes "In the last two years, over 200 million Indian nationals have had their fingerprints and photographs taken and irises scanned, and given a unique 12-digit number that should identify them everywhere and to everyone. This is only the beginning, and the goal is to do the same with the entire population (1.2 billion), so that poorer Indians can finally prove their existence and identity when needed for getting documents, getting help from the government, and opening bank and other accounts. This immense task needs a database that can contain over 12 billion fingerprints, 1.2 billion photographs, and 2.4 billion iris scans, can be queried from diverse devices connected to the Internet, and can return accurate results in an extremely short time."

ericjones12398 writes "Just one decade ago, sequencing an entire human genome cost upwards of $10 million and took about three years to complete. Now, several companies are racing to provide technology that can sequence a complete human genome in one day for less than $1,000. 'A genome sequence for $1,000 was a pipe dream, just a few years ago,' said Dr. Richard Gibbs, director of the Human Genome Sequencing Center at Baylor College of Medicine, 'A $1,000 genome in less than one day was not even on the radar, but will transform the clinical applications of sequencing."

gollum123 writes with this excerpt from the NY Times: "For more than a decade, almost all processed foods in the United States — cereals, snack foods, salad dressings — have contained ingredients from plants whose DNA was manipulated in a laboratory. Regulators and many scientists say these pose no danger. But as Americans ask more pointed questions about what they are eating, popular suspicions about the health and environmental effects of biotechnology are fueling a movement to require that food from genetically modified crops be labeled, if not eliminated. The most closely watched labeling effort is a proposed ballot initiative in California that cleared a crucial hurdle this month, setting the stage for a probable November vote that could influence not just food packaging but the future of American agriculture. Tens of millions of dollars are expected to be spent on the election showdown. It pits consumer groups and the organic food industry, both of which support mandatory labeling, against more conventional farmers, agricultural biotechnology companies like Monsanto and many of the nation's best-known food brands like Kellogg's and Kraft."

An anonymous reader writes "You don't hear too much about biological computing but in research published this week in the Proceedings of the National Academy of Sciences, scientists reveal they have devised the genetic equivalent of a binary digit (full article, freely available) — a 'bit' in data parlance. 'It took us three years and 750 tries to make it work, but we finally did it,' according to Jerome Bonnet, of research which describes, a method for repeatedly encoding, storing and erasing digital data within the DNA of living cells."

redletterdave writes with an update to news from a few months ago that France had banned the growing of Monsanto's genetically modified corn. After reviewing the evidence France submitted in support of the ban, the European Food Safety Authority has now rejected it. An official opinion (PDF) stated that they "could not identify any new science-based evidence indicating that maize MON 810 cultivation in the EU poses a significant and imminent risk to the human and animal health or the environment."