Imagine that you are at 33 Flatbush Ave. in the Brooklyn borough of what David Letterman calls "the world's greatest city." You go to the 7th floor. Congratulations. You have found New York City's community biolab, Genspace. It's a well-equipped facility without a single mad scientist in sight. Indeed, everyone here seems as happy as the people you see in a makerspace -- which should not be surprising, since Genspace is essentially a makerspace for biologists. It is confined to non-hazardous experiments, but there is plenty going on, including ongoing projects and courses with titles like DIY Neuroscience: Controlling Behavior from the Inside. You can keep up with Genspace by following their blog. And of course, if you're in the neighborhood you should stop in. It's a welcoming environment, dedicated to the idea that science is for everyone, not just a chosen few.

An anonymous reader writes "Stanford researchers have developed a new algorithm (Abstract only) that significantly improves the control and performance of neural prosthetics — brain-controlled computer interfaces for individuals suffering from spinal cord injury and neurodegenerative disease to aid interaction with computers, drive electronic wheelchairs, and control robotic arms and legs. With this algorithm, monkeys implanted with multielectrode arrays in motor regions of their brain controlled a computer cursor more quickly and accurately than ever before, including navigation around obstacles. Further, the system maintained this high performance across 4 years, demonstrating long-term reliability. These improvements in performance and robustness are crucial for clinically-useful neural prosthetics, and pave the way for success in clinical trails."

sciencehabit writes "Here's a twist: Scientists have designed a flexible, yarn-like artificial muscle that can also pack a punch. It can contract in 25 milliseconds—a fraction of the time it takes to blink an eye—and can generate power 85 times as great as a similarly sized human muscle. The new muscles are made of carbon nanotubes filled with paraffin wax that can twist or stretch in response to heat or electricity. When the temperature rises, the wax melts and forces the nanotubes to contract. Such artificial muscles, the researchers say, could power smart materials, sensors, robots, and even devices inside the human body."

An anonymous reader writes "Scientists announced Wednesday that they have mapped the entire genome of the domestic pig, revealing that besides providing tasty bacon and sausages, the animal may also be useful in fighting human diseases. The study published in the journal Nature found that pigs and humans share 112 DNA mutations that have previously been linked to diseases like obesity, diabetes, dyslexia, Parkinson's and Alzheimer's, according to US and European researchers. Researchers said that because pigs share many of the same complex genetic diseases as humans, the animals would serve as excellent models for studying the underlying biology of human disease."

New submitter DaemonDan writes "The first successful pregnancy by IVF was accomplished over 50 years ago, essentially creating a multi-billion dollar industry. Many scientists are trying to take it one step farther with a 100% test tube baby brought to term in an artificial womb. 'Cornell University's Dr. Hung-Ching Liu has engineered endometrial tissues by prompting cells to grow in an artificial uterus. When Liu introduced a mouse embryo into the lab-created uterine lining, "It successfully implanted and grew healthy," she said in this New Atlantis Magazine article. Scientists predict the research could produce an animal womb by 2020, and a human model by early 2030s.' The author of the article seems to believe that birth via artificial wombs could become the new norm, but is it really feasible, desirable or even affordable for the majority of Earth's population?"

eldavojohn writes "Professor Gerald "Jerry" Crabtree of Stanford's Crabtree Laboratory published a paper (PDF) that has appeared in two parts in Trends in Genetics. The paper opens with a very controversial suggestion: 'I would be willing to wager that if an average citizen from Athens of 1000 BC were to appear suddenly among us, he or she would be among the brightest and most intellectually alive of our colleagues and companions.' From there, Crabtree speculates we're on the decline of human intelligence and we have been for at least a couple millennia. His argument suggests agriculture and, following from that, cities, have allowed us to break free of some environmental forces on competitive genetic mutations — a la Mike Judge's theory. However, the conclusion of the paper urges humans to keep calm and carry on, as any attempt to fix this genetic trend would almost certainly be futile and disturbing."

An anonymous reader writes "A new neural interface delicate enough not to damage nerve tissue, but resilient enough to last decades has been made. Made from a single carbon fiber and coated with chemicals, the technology is believed to be fully resistant to proteins in the brain. From the article: 'The new microthread electrode, designed to pick up signals from a single neuron as it fires, is only about 7 micrometers in diameter. That is the thinnest yet developed, and about 100 times as thin as the conventional metal electrodes widely used to study animal brains. “We wanted to see if we could radically change implant technology,” says Takashi Kozai, a researcher at the University of Pittsburgh and the lead author on the paper, published today in the journal Nature Materials. “We want to see an electrode that lasts 70 years.”'"

dryriver sends this excerpt from the Guardian: "Scientists have pinpointed a new treasure trove in our oceans: micro-organisms that contain millions of previously unknown genes and thousands of new families of proteins. These tiny marine wonders offer a chance to exploit a vast pool of material that could be used to create innovative medicines, industrial solvents, chemical treatments and other processes, scientists say. Researchers have already created new enzymes for treating sewage and chemicals for making soaps from material they have found in ocean organisms. 'The potential for marine biotechnology is almost infinite,' says Curtis Suttle, professor of earth, ocean and atmospheric sciences at the University of British Columbia. 'It has become clear that most of the biological and genetic diversity on Earth is – by far – tied up in marine ecosystems, and in particular in their microbial components. By weight, more than 95% of all living organisms found in the oceans are microbial. This is an incredible resource.'"

cylonlover writes "Our ears work by converting the vibrations of the eardrum into electrochemical signals that can be interpreted by the brain. The current for those signals is supplied by an ion-filled chamber deep within the inner ear – it's essentially a natural battery. Scientists are now looking at using that battery to power devices that could be implanted in the ear, without affecting the recipient's hearing. The 'battery chamber' is located in the cochlea. It is internally divided by a membrane, some of the cells of which are designed to pump ions. The arrangement of those specialized cells, combined with an imbalance of potassium and sodium ions on opposite sides of the membrane, are what creates the electrical voltage. A team of scientists from MIT, the Massachusetts Eye and Ear Infirmary, and the Harvard-MIT Division of Health Sciences and Technology have recently succeeded in running an ultra-low-power radio-transmitting chip using power from these battery chambers – in guinea pigs' ears."

ananyo writes "Proteins are an enormous molecular achievement: chains of amino acids that fold spontaneously into a precise conformation, time after time, optimized by evolution for their particular function. Yet given the exponential number of contortions possible for any chain of amino acids, dictating a sequence that will fold into a predictable structure has been a daunting task. Now researchers report that they can do just that. By following a set of rules described in a paper published in Nature (abstract), a husband and wife team from David Baker's laboratory at the University of Washington in Seattle has designed five proteins from scratch that fold reliably into predicted conformations. The work could eventually allow scientists to custom design proteins with specific functions."

MrSeb writes "Engineers at the University of Michigan have created a pacemaker that is powered by the beating of your heart — no batteries required. The technology behind this new infinite-duration pacemaker is piezoelectricity. Piezoelectricity is is literally 'pressure electricity,' and it relates to certain materials that generate tiny amounts of electricity when deformed by an external force — which, in the case of the perpetual pacemaker, the vibrations in your chest as your heart pumps blood around your body. Piezoelectric devices generate very small amounts of power — on the order of tens of milliwatts — but it turns out that pacemakers require very little power. In testing, the researchers' energy harvester generated 10 times the required the power to keep a pacemaker firing. Currently, pacemakers are battery powered — and the battery generally need to be replaced every few years, which requires surgery. According M. Amin Karami, the lead researcher, 'Many of the patients are children who live with pacemakers for many years,' he said. 'You can imagine how many operations they are spared if this new technology is implemented.' This piezoelectric energy harvester is about half the size of a conventional battery, too, which is presumably a good thing."

An anonymous reader writes "4 years ago I read about experimental targeted muscle reinnervation (TMR) surgery on Slashdot. 3 years ago I crashed my motorcycle and had my leg amputated — at which time I had TMR done. Today I climbed 103 floors of the Willis Tower in Chicago with a experimental prosthetic using TMR. Thanks, Slashdot."

Hugh Pickens writes writes "The Atlantic reports that experts in genetics and microbiology are convinced we may be only a few years away from the development of advanced, genetic bio-weapons able to target a single human being based on their DNA. The authors paint a scenario of the development of a virus that causes only mild flu in the general population but when the virus crosses paths with cells containing a very specific DNA sequence, the sequence would act as a molecular key to unlock secondary functions that would trigger a fast-acting neuro-destructive disease that produces memory loss and, eventually, death. The requisite equipment including gene sequencers, micro-array scanners, and mass spectrometers now cost over $1 million but on eBay, it can be had for as little as $10,000. According to Ronald Kessler, the author of the 2009 book In the President's Secret Service, Navy stewards gather bedsheets, drinking glasses, and other objects the president has touched—they are later sanitized or destroyed—in an effort to keep would-be malefactors from obtaining his genetic material. However no amount of Secret Service vigilance can ever fully secure the president's DNA, because an entire genetic blueprint can now be produced from the information within just a single cell. How to protect the President? The authors propose open-sourcing the president's genetic information to a select group of security-cleared researchers who could follow in the footsteps of the computer sciences, where 'red-team exercises,' are extremely common practices so a similar testing environment could be developed for biological war games. 'Advances in biotechnology are radically changing the scientific landscape. We are entering a world where imagination is the only brake on biology,' write the authors. 'In light of this coming synbio revolution, a wider-ranging relationship between scientists and security organizations—one defined by open exchange, continual collaboration, and crowd-sourced defenses—may prove the only way to protect the president.'"

sciencehabit writes "A tonic of gut microbes may be the secret recipe for treating a common hospital scourge. Researchers have pinpointed the exact mix of microbes required to cure mice of chronic infection by Clostridium difficile. The hard-to-treat bacterium infects alomst 336,000 in the US each year and causes bloating, pain, & diarrhea. A similar bacterial cocktail may be able to replace the current controversial treatment involving the intake of a healthy person's fecal matter to restore the right balance of microbes in the gut."

Tator Tot writes "Grape pomace, the mashed up skins and stems left over from making wine and grape juice, could serve as a good starting point for ethanol production, according to a new study (from the Journal of Agriculture and Food Chemistry). Due to growing interest in biofuels, researchers have started looking for cheap and environmentally sustainable ways to produce such fuels, especially ethanol. Biological engineer Jean VanderGheynst at the University of California, Davis, turned to grape pomace, because winemakers in California alone produce over 100,000 tons of the fruit scraps each year, with much of it going to waste."

An anonymous reader writes in a story about a neat potential use for spider silk. "Many people have heard that spider silk is a sort of supermaterial: stronger than steel, tougher than Kevlar, and yet incredibly malleable and flexible. But the silk has other properties that make it ideal for use in electronic devices. Light can travel through a silk strand as easily as it does through a fiber optic cable. 'When we first tested spider silk, we didn’t know what to expect,' said physicist Nolwenn Huby of the Institut de Physique de Rennes in France. 'We thought, "Why not try this as an optical fiber to propagate light?'" Huby and her team were able to transmit laser light down a short strand of the silk on an integrated circuit chip. The silk worked much like glass fiber optic cables, meaning it could carry information for electronic devices, though it had about four orders of magnitude more loss than the glass. Huby said that with a coating and further development, the silk could one day have better transmission capabilities. She will present her results at this year’s Frontiers in Optics conference, Oct. 14 to 18 in Rochester, New York.

Sam Bagot and Will Bratton operate Horto Domi (hortodomi.com), an agricultural project they describe as "beyond organic." They're working with small prefab greenhouses, adding sensors and Arduino-actuated controls, and even including an earthworm breeding area in most domes, because earthworms are good for the soil and can increase plant production. If you're the kind of person whose plants always seem to shrivel up and die, this may be a great way to garden. With watering and other functions automated, it looks like all you have to do is set your controls, plant what you want to grow, and wait for the "time to harvest" alarm to go off. Okay, it might not be that simple, but Sam and Will say their gardening method saves a lot of energy and time. It also looks like fun, besides being an easy way to grow your own 100% organic fruits and vegetables.

another random user writes with this quote from Nature News: "Few researchers have given credence to claims that samples of dinosaur DNA have survived to the present day, but no one knew just how long it would take for genetic material to fall apart. Now, a study of fossils found in New Zealand is laying the matter to rest — and putting paid to hopes of cloning a Tyrannosaurus rex (abstract). After cell death, enzymes start to break down the bonds between the nucleotides that form the backbone of DNA, and micro-organisms speed the decay. In the long run, however, reactions with water are thought to be responsible for most bond degradation. Groundwater is almost ubiquitous, so DNA in buried bone samples should, in theory, degrade at a set rate. Determining that rate has been difficult because it is rare to find large sets of DNA-containing fossils with which to make meaningful comparisons. To make matters worse, variable environmental conditions such as temperature, degree of microbial attack and oxygenation alter the speed of the decay process. By comparing the specimens' ages and degrees of DNA degradation, the researchers calculated that DNA has a half-life of 521 years. That means that after 521 years, half of the bonds between nucleotides in the backbone of a sample would have broken; after another 521 years half of the remaining bonds would have gone; and so on."

tomhath writes with this exerpt from a Reuters story: "The U.S. Supreme Court agreed Friday to hear an Indiana farmer's appeal that challenges the scope of Monsanto Co.'s patent rights on its Roundup Ready seeds. Mr. Bowman bought and planted 'commodity seeds' from a grain elevator. Those soybean seeds were a mix and included some that contained Monsanto's technology. The Supreme Court agreed to hear the case over the objections of the Obama administration, which had urged the justices to leave the lower court rulings in place."

ananyo writes "Japanese researchers have coaxed mouse stem cells into becoming viable eggs that produce healthy offspring. Last year, the same team successfully used mouse stem cells to make functional sperm (other groups have produced sperm cells in vitro). The researchers used a cocktail of growth factors to transform stem cells into egg precursors. When they added these egg precursor cells to embryonic ovary tissue that did not contain sex cells, the mixture spontaneously formed ovary-like structures, which they then grafted onto natural ovaries in female mice. After four weeks, the stem-cell-derived cells had matured into oocytes. The team removed the oocytes from the ovaries, fertilized them and transplanted the embryos into foster mothers. The offspring that were produced grew up to be fertile themselves."