ananyo writes "Francis Collins, director of the National Institutes of Health, has brokered a deal with the family of Henrietta Lacks to release the genetic sequence of the HeLa cell line to researchers. The HeLa cell line was established in 1951 from a biopsy of a cervical tumour taken from Henrietta Lacks, a working-class African-American woman living near Baltimore. The cells were taken without the knowledge or permission of her or her family, and they became the first human cells to grow well in a lab. They contributed to the development of a polio vaccine, the discovery of human telomerase and countless other advances. Controversy erupted earlier this year after researchers published the sequence without the permission of the Lacks family. In a Q&A with the journal Nature, Collins explains how the deal was reached."

Zothecula writes "Synthetic crop fertilizers are a huge source of pollution. This is particularly true when they're washed from fields (or leach out of them) and enter our waterways. Unfortunately, most commercial crops need the fertilizer, because it provides the nitrogen that they require to survive. Now, however, a scientist at the University of Nottingham has developed what he claims is an environmentally-friendly process, that allows virtually any type of plant to obtain naturally-occurring nitrogen directly from the atmosphere." The process involves injecting a bacteria that colonizes the plant and fixes atmospheric nitrogen in exchange for a bit of sugar, similar to soybeans. Only this bacteria will readily colonize most any plant.

vinces99 writes "Researchers have developed a new method that can look at a specific segment of DNA and pinpoint a single mutation, which could help diagnose and treat diseases such as cancer and tuberculosis. These small changes can be the root of a disease or the reason some infectious diseases resist certain antibiotics. The findings were published online July 28 in the journal Nature Chemistry. 'We've really improved on previous approaches because our solution doesn't require any complicated reactions or added enzymes, it just uses DNA,' said lead author Georg Seelig, a University of Washington assistant professor of electrical engineering and of computer science and engineering. 'This means that the method is robust to changes in temperature and other environmental variables, making it well-suited for diagnostic applications in low-resource settings.' The researchers designed probes that can pick out mutations in a single base pair in a target stretch of DNA. The probes allow researchers to look in much more detail for variations in long sequences up to 200 base pairs while current methods can detect mutations in stretches of up to only 20."

biobricks writes "A New York Times story says the Florida orange crop is threatened by an incurable disease and traces the efforts of one company to insert a spinach gene in orange trees to fend it off. Not clear if consumers will go for it though." The article focuses on oranges, but touches on the larger world of GMO crop creation as well.

An anonymous reader writes "Scientists have silenced the extra copy of a chromosome that causes Down syndrome in laboratory stem cells, offering the first evidence that it may be possible to correct the genes responsible for the disorder. The discovery provides the first evidence that the underlying genetic defect responsible for Down syndrome can be suppressed in cells in culture."

MTorrice writes "A new study suggests there's more to nanoparticle toxicology than cell life and death. Although immune cells treated with iron oxide particles appeared healthy in standard toxicology tests, they struggled to perform one of their key jobs: engulfing pathogenic bacteria. The researchers wonder if exposure to significant levels of the nanoparticles could lead to dysfunction in people's immune systems."

An anonymous reader writes "A Newtown couple, both scientists, who lost their daughter in the school shooting, are wondering whether there were clues in the shooter's physiological makeup — his DNA, his blood, his brain chemistry. They are now involved in a search for biomarkers, similar to those that may indicate disease, for violence. They are raising money to help fund this research, but the effort is running into obstacles, in part, over ethical concerns. 'I'm not opposed to research on violence and biomarkers, but I'm concerned about making too big of a leap between biomarkers and violence,' said Troy Duster, a researcher at the University of California at Berkeley. There is concern that science may find biomarkers long before society can deal with its implications."

aarondubrow writes "Researchers reported results in Nature Communications on a new way of sculpting tailor-made fluid flows by placing tiny pillars in microfluidic channels [abstract; article is paywalled]. The method could allow clinicians to better separate white blood cells in a sample, increase mixing in industrial applications, and more quickly perform lab-on-a-chip-type operation. Using the Ranger and Stampede supercomputers, the researchers ran more than 1,000 simulations representing combinations of speeds, thicknesses, heights or offsets that produce unique flows. This library of transformations will help the broader community design and use sculpted fluid flows."

HonorPoncaCityDotCom writes "For all the wonders of fresh broccoli, in most parts of the country it is only available from local growers during the cooler weeks at either end of the growing season, nowhere near long enough to become a fixture in grocery stores or kitchens. But now Michael Moss writes in the NY Times that Thomas Bjorkman is out to change all that by creating a new version of the plant that can thrive in hot, steamy summers like those in New York, South Carolina or Iowa and is easy and inexpensive enough to grow in large volumes. And Bjorkman's quest doesn't stop there: His crucifer is also crisp, subtly sweet and utterly tender when eaten fresh-picked and aims to maximize the concentration of glucoraphanin, a mildly toxic compound used by plants to fight insects that in humans may stimulate our bodies' natural chemical defenses to aid in preventing cancer and warding off heart disease. The Eastern Broccoli Project's goal is to create a regional food network for an increasingly important and nutritious vegetable that may serve as a model network for other specialty crops to help shift American attitudes toward fruits and vegetables by increasing their allure and usefulness in cooking, while increasing their nutritional loads. 'If you've had really fresh broccoli, you know it's an entirely different thing,' says Bjorkman, a plant scientist at Cornell University. 'And if the health-policy goal is to vastly increase the consumption of broccoli, then we need a ready supply, at an attractive price.'"

Ogi_UnixNut writes "Scientists in Japan have succeeded in cloning a mouse from a drop of blood. From the BBC: 'Circulating blood cells collected from the tail of a donor mouse were used to produce the clone, a team at the Riken BioResource Center reports in the journal Biology of Reproduction.' The female mouse managed to live a normal lifespan and could reproduce, according to the researchers."

the_newsbeagle writes "Fast, cheap genetic sequencing machines have the potential to revolutionize science and medicine--but only if geneticists can figure out how to deal with the floods of data their machines are producing. That's where computer scientists can save the day. In this article from IEEE Spectrum, two computational biologists explain how they're borrowing big data solutions from companies like Google and Amazon to meet the challenge. An explanation of the scope of the problem, from the article: 'The roughly 2000 sequencing instruments in labs and hospitals around the world can collectively generate about 15 petabytes of compressed genetic data each year. To put this into perspective, if you were to write this data onto standard DVDs, the resulting stack would be more than 2 miles tall. And with sequencing capacity increasing at a rate of around three- to fivefold per year, next year the stack would be around 6 to 10 miles tall. At this rate, within the next five years the stack of DVDs could reach higher than the orbit of the International Space Station.'"

First time accepted submitter bmahersciwriter writes "Hugh Rienhoff has searched for more than a decade for the cause of a mysterious constellation of clinical features in his daugther Bea: skinny legs, curled fingers and always the specter that she might have a high risk of cardiovascular complications. He even bought second hand lab equipment to prepare some of her genes for sequencing in his basement. Now, he has an answer."

sciencehabit writes "Scientists have sequenced the oldest genome to date—and shaken up the horse family tree in the process. Ancient DNA derived from a horse fossil that's between 560,000 and 780,000 years old suggests that all living equids—members of the family that includes horses, donkeys, and zebras—shared a common ancestor that lived at least 4 million years ago, approximately 2 million years earlier than most previous estimates. The discovery offers new insights into equine evolution and raises the prospect of recovering and exploring older DNA than previously thought possible."

An anonymous reader writes "An NJIT research professor known for his cutting-edge work with carbon nanotubes is overseeing the manufacture of a prototype lab-on-a-chip that would someday enable a physician to detect disease or virus from just one drop of liquid, including blood. 'Scalable nano-bioprobes with sub-cellular resolution for cell detection,' (Elsevier, Vol. 45), which will publish on July 15, 2013 but is available now online, describes how NJIT research professors Reginald Farrow and Alokik Kanwal, his former postdoctoral fellow, and their team have created a carbon nanotube-based device to noninvasively and quickly detect mobile single cells with the potential to maintain a high degree of spatial resolution."

First time accepted submitter overmod writes "Browsing on a completely unrelated subject, I came across this New York Times description of Solazyme. From the article: '...in 2003, Mr. Wolfson packed up and moved from New York to Palo Alto, Calif., where Mr. Dillon lived. They started a company called Solazyme. In mythical Valley tradition, they worked in Mr. Dillon’s garage, growing algae in test tubes. And they found a small knot of investors attracted by the prospect of compressing a multimillion-year process into a matter of days. Now, a decade later, they have released into the marketplace their very first algae-derived oil produced at a commercial scale. Yet the destination for this oil — pale, odorless and dispensed from a small matte-gold bottle with an eyedropper — is not gas tanks, but the faces of women worried about their aging skin.' What I find interesting is the model they've adopted for short-term growth, which I would not have seen coming from a technology oriented toward biofuel production. Leads me to wonder what other nominally-green technologies that would otherwise be slow if not impossible to scale to workable businesses might have 'niche' applications, with high perceived marginal value, that could be used to boost capital, rather than relying on donations, grants, or nebulous save-the-planet goodwill."

MTorrice writes "Crab shells usually are just a nuisance that you have to crack and dig through to get the delicious meat inside. But one team of materials scientists thinks the shells could help them fabricate materials for long lasting batteries. The team used the nanostructures (abstract) found in the crustacean shells as templates to make sulfur and silicon electrode materials for lithium-ion batteries. Sulfur or silicon electrodes have a 10-times greater theoretical energy storage capacity than electrodes used in commercial batteries."

sfcrazy writes "A top Monsanto executive has won the prestigious World Food Prize. Secretary of State John Kerry announced the award where Robert T. Fraley, the executive vice president and CTO of Monsanto, won the prize along with two other scientists from Belgium and the US. The award was given for devising a method to insert genes from another organism into plant cells, which could produce new genetic lines with highly favorable traits."

Zothecula writes "Applied DNA Sciences (ADNAS) has developed a new approach to solve crimes using DNA tagging. The difference is that instead of tagging the objects being stolen, the company's system tags the perpetrator with DNA. While this has been tried before by applying the DNA to a fleeing criminal with a gun, ADNAS has adopted a more subtle approach."

ColdWetDog writes "The ongoing story of Myriad Genetics versus the rest of the world has come to an end. In a 9-0 decision, the US Supreme Court has decided that human genes cannot be patented. From a brief Bloomberg article: 'Writing for the court, Justice Clarence Thomas said isolated DNA is a "product of nature and not patent eligible merely because it has been isolated." At the same time, Thomas said synthetic molecules known as complementary DNA, or cDNA, can be patented because they require a significant amount of human manipulation to create.' Seems perfectly sane. Raw genes, the ones you find in nature are, wait for it — natural. Other bits of manipulated DNA / RNA / protein which take skill and time to create are potentially patentable. Oddly, Myriad Genetics stock actually rose on that information." Adds reader the eric conspiracy: "The result for Myriad is that they still have protection for their test, however the decision also allows researchers to work with the DNA sequences that are predecessors to the cDNA used in the test." Here's an AP report on the ruling, as carried by the Washington Post.

sciencehabit writes "Despite a slow economy, business in genomics has boomed and has directly and indirectly boosted the U.S. economy by $965 billion since 1988, according to a new study (pdf). In 2012 alone, genomics-related research and development, along with relevant industry activities, contributed $31 billion to the U.S. gross national product and helped support 152,000 jobs, the biomedical funding advocacy group United for Medical Research announced today in Washington, D.C. Based on total U.S. spending, the country gets $65 back for every $1 it spends on the field."