ananyo (2519492) writes "People are living longer, which is good. But old age often brings a decline in mental faculties and many researchers are looking for ways to slow or halt such decline. One group doing so is led by Dena Dubal of the University of California, San Francisco, and Lennart Mucke of the Gladstone Institutes, also in San Francisco. Dr Dubal and Dr Mucke have been studying the role in aging of klotho, a protein encoded by a gene called KL. A particular version of this gene, KL-VS, promotes longevity. One way it does so is by reducing age-related heart disease. Dr Dubal and Dr Mucke wondered if it might have similar powers over age-related cognitive decline. What they found was startling. KL-VS did not curb decline, but it did boost cognitive faculties regardless of a person's age by the equivalent of about six IQ points. If this result, just published in Cell Reports, is confirmed, KL-VS will be the most important genetic agent of non-pathological variation in intelligence yet discovered."

An anonymous reader writes "The fear of flying or of skittering spiders can mean more than just a momentary increase in heart rate and a pair of sweaty palms. A hard-core phobia can lead to crippling anxiety. Now an international team of researchers says it believes it has found a way to silence the gene that feeds phobic fear via a novel mechanism of gene regulation associated with fear extinction. The notion appears to be that phobias arise from experiences that have left an outsized imprint on gene expression, and that undoing this can undo the anxiety itself. The study was published this month (abstract) in the Proceedings of the National Academy of Sciences."

Hugh Pickens DOT Com (2995471) writes "Evan Halper writes in the LA Times that with efforts to reduce carbon emissions lagging, researchers, backed by millions of dollars from the federal government, are looking for ways to protect key industries from the impact of climate change by racing to develop new breeds of farm animals that can stand up to the hazards of global warming. ""We are dealing with the challenge of difficult weather conditions at the same time we have to massively increase food production" to accommodate larger populations and a growing demand for meat, says Agriculture Secretary Tom Vilsack. For example a team of researchers is trying to map the genetic code of bizarre-looking African naked-neck chickens to see if their ability to withstand heat can be bred into flocks of US broilers. "The game is changing since the climate is changing," says Carl Schmidt. "We have to start now to anticipate what changes we have to make in order to feed 9 billion people," citing global-population estimates for 2050." (More below.)

sciencehabit (1205606) writes "Scientists have found that mice feel 36% less pain when a male researcher is in the room, versus a female researcher. The rodents are also less stressed out. The effect appears to be due to scent molecules that male mammals (including humans, dogs, and cats) have been emitting for eons. The finding could help explain why some labs have trouble replicating the results of others, and it could cause a reevaluation of decades of animal experiments: everything from the effectiveness of experimental drugs to the ability of monkeys to do math. Male odor could even influence human clinical trials."

assertation (1255714) writes "Bill Gates and the founders of Twitter are betting millions that meat lovers will embrace a new plant-based product that mimics the taste of chicken and beef. Meat substitutes have had a hard time making it to the dinner tables of Americans over the years, but the tech giants believe these newest products will pass the "tastes like chicken" test. Gates has met several times with Ethan Brown, whose product, Beyond Meat, is a mash-up of proteins from peas and plants."

sciencehabit writes "Many people with profound hearing loss have been helped by devices called cochlear implants, but their hearing is still far from perfect. They often have trouble distinguishing different musical pitches, for example, or hearing a conversation in a noisy room. Now, researchers have found a clever way of using cochlear implants to deliver new genes into the ear — a therapy that, in guinea pigs, dramatically improves hearing (abstract)."

Lasrick (2629253) writes "Really interesting piece by Emma Rosenblum about women freezing their eggs in order to take 'biological clock' pressure off while they pursue careers: 'Not since the birth control pill has a medical technology had such potential to change family and career planning. The average age of women who freeze their eggs is about 37, down from 39 only two years ago... And fertility doctors report that more women in their early 30s are coming in for the procedure. Not only do younger women have healthier eggs, they also have more time before they have to use them.'"

New submitter Chipmunk100 (3619141) writes "Using corn crop residue to make ethanol and other biofuels reduces soil carbon and can generate more greenhouse gases than gasoline, according to a study published today in the journal Nature Climate Change. The findings by a University of Nebraska-Lincoln team of researchers cast doubt on whether corn residue can be used to meet federal mandates to ramp up ethanol production and reduce greenhouse gas emissions."

mr crypto (229724) writes "A group of scientists and food activists are launching a campaign to change the rules that govern seeds. They're releasing 29 new varieties of crops under a new 'open source pledge' that's intended to safeguard the ability of farmers, gardeners and plant breeders to share those seeds freely."

Trax3001BBS (2368736) writes in with news about a breakthrough in creating stem cells perfectly matched to a person's DNA. "...Lanza's group used caffeine to prevent the fused egg from dividing prematurely. Rather than leaving the egg with its newly introduced DNA for 30 minutes before activating the dividing stage, they let the eggs rest for about two hours. This gave the DNA enough time to acclimate to its new environment and interact with the egg's development factors, which erased each of the donor cell's existing history and reprogrammed it to act like a brand new cell in an embryo.'"

sciencehabit (1205606) writes "The U.S. biomedical science system 'is on an unsustainable path' and needs major reform, four prominent researchers say. Researchers should 'confront the dangers at hand,' the authors write, and 'rethink' how academic research is funded, staffed, and organized. Among other issues, the team suggests that the system may be producing too many new researchers and forcing them to compete for a stagnating pool of funding."

An anonymous reader writes "A team of CSIRO scientists has discovered the holy grail of aquaculture by developing the world's first fish-free prawn food: Novaq. According to the article there is intense global interest in Novaq because it solves one of the farmed prawn industry's biggest problems — its reliance on wild fisheries as a core ingredient in prawn food. The Novaq formula is a closely guarded secret, but it is known that the product is based on microscopic marine organisms. Not only will the new feed introduce greater sustainability into a growth industry but prawns fed on the new diet grow 40% faster and are healthier and more robust."

ananyo (2519492) writes "Scientists at Edinburgh University have successfully persuaded an organ to regenerate inside an animal. As they report in the journal Development, they have treated, in mice, an organ called the thymus, which is a part of the immune system that runs down in old age. Instead of adding stem cells they have stimulated their animals' thymuses to make more of a protein called FOXN1. This is a transcription factor (a molecular switch that activates genes). The scientists knew from earlier experiments that FOXN1 is important for the embryonic development of the thymus, and speculated that it might also rejuvenate the organ in older animals. They bred a special strain of mice whose FOXN1 production could be stimulated specifically in the thymus by tamoxifen, a drug more familiar as a treatment for breast cancer. In one-year-olds, stimulating FOXN1 production in the thymus caused it to become 2.7 times bigger within a month. In two-year-olds the increase was 2.6 times. Moreover, when the researchers studied the enlarged thymuses microscopically, and compared them with those from untreated control animals of the same ages, they found that the organs' internal structures had reverted to their youthful nature."

v3rgEz (125380) writes "It sounds like a scare from 1970s Cold War propaganda or a subplot from the popular TV series "The Americans," but the FBI says the threat is real: Russian investment firms may be looking to steal high-tech intelligence from Boston-area companies to give to their country's military. Many of the firms under scrutiny are in the Boston area, including those partnered with a number of area biotech companies and with ties to MIT." And while the FBI says this could be happening, as the article points out, this pronouncement seems to be based on plausibility rather than specific incidents of such theft. One relevant excerpt: "The FBI warning comes as the Obama administration has increased pressure on Russia for its annexation of the former Ukrainian territory of Crimea by levying sanctions on some business leaders close to President Vladimir Putin. In March, the US Commerce Department banned new licenses for the export to Russia of defense-related products and “dual-use” technologies that could have military applications."

According to reader sciencehabit (1205606), Kenneth Ka-Ho Lee, the embryologist who has been live-blogging his attempt to reproduce a new kind of stem cells, has given up, writing on this Research Gate page, "I don't think STAP cells exist and it will be a waste of manpower and research funding to carry on with this experiment any further." From the linked article: "Though he is giving up, he hopes others will continue to investigate whether the new approach – which has dogged by controversy and claims of research misconduct — can really lead to stem cells."

sciencehabit (1205606) writes "Wood is great for building and heating homes, but it's the bane of biofuels. When converting plants to fuels, engineers must remove a key component of wood, known as lignin, to get to the sugary cellulose that's fermented into alcohols and other energy-rich compounds. That's costly because it normally requires high temperatures and caustic chemicals. Now, researchers in the United States and Canada have modified the lignin in poplar trees to self-destruct under mild processing conditions—a trick that could slash the cost of turning plant biomass into biofuels."

KentuckyFC (1144503) writes "The single-celled organism slime mold, or Physarum polycephalum, is an extraordinary creature. It explores its world by extending protoplasmic tubes into its surroundings in search of food and it does this rather well. Various researchers have exploited this process to show how Physarum can find optimal routes between different places and even solve mazes. Now one researcher has worked out how to use these protoplasmic tubes as clock-like electronic oscillators. His experiment was straightforward. He encouraged the growth of protoplasmic tubes between two blobs of agar sitting on electrical contacts. He then measured the resistance of the tubes at various voltages. This turns out to be about 6 megaohms. But the results show something else too: that the resistance oscillates over a period of about 73 seconds. That's due to the tubes contracting as waves of calcium ions pass through them. So altering the period of oscillation should be possible by influencing the production of calcium ions, perhaps using light or biochemistry. Electronic oscillators are significant because they are basic drivers of almost all active electronic devices. But this guy's goal is bigger than this. The plan is to grow a "Physarum chip" that acts as a general purpose computer, a device that will need some kind of oscillator or clock to co-ordinate activity, just as in an ordinary processor, although speed will not be its chief characteristic."

An anonymous reader writes "Genome sequencing is getting faster and cheaper every year. This article points out that in the not-too-distant future, a DNA test will be a common diagnostic tool for doctors. It's a good thing for figuring out what's wrong with you — but there will unintended consequences. The test will also return information about conditions and diseases you're likely to get, which will spur more frequent testing — which can be extremely uncomfortable and/or expensive — as well as more frequent worrying. Should people be able to opt-out of this knowledge? Even if they do, should the information go into the patient's medical record? It likely will, and then the next doctor may be in the difficult position of not knowing what she can discuss with the patient. A new decision from the American College of Medical Genetics has recommended giving patients the option of not having the information gathered at all. It can get more complicated, too: '[G]eneticists and bioethicists are already discussing scenarios where patients may approach such decisions more like a menu, saying they want to know about increased risk of heart disease but not cancer, for example.'"

Lasrick (2629253) writes "Martin Furmanski, a medical doctor and medical historian, writes of the laboratory escapes of high-consequence pathogens that have occurred in recent decades (including several instances of smallpox!). The article explores 'gain of function" experiments-- experiments in which researchers manipulate dangerous pathogens to increase communicability among humans, and whether the benefit we see from those experiments outweighs the incredible risk. 'Many other laboratory escapes of high-consequence pathogens have occurred, resulting in transmission beyond laboratory personnel. Ironically, these laboratories were working with pathogens to prevent the very outbreaks they ultimately caused. For that reason, the tragic consequences have been called "self-fulfilling prophecies.''"

Science_afficionado (932920) writes "Vanderbilt University scientists reported significant progress toward creating 'homo minutus' — a benchtop human — at the Society of Toxicology meeting on Mar. 26 in Phoenix. The advance is the successful development and analysis of a human liver construct//organ-on-a-chip that responds to exposure to a toxic chemical much like a real liver. The achievement is the first result from a five-year, $19 million multi-institutional effort led by Los Alamos National Laboratory (LANL), to develop four interconnected human organ constructs — liver, heart, lung and kidney — that are based on a highly miniaturized platform nicknamed ATHENA (Advanced Tissue-engineered Human Ectypal Network Analyzer). The project is supported by the Defense Threat Reduction Agency. Similar programs to create smaller-scale organs-on-chips are underway at the Defense Advanced Research Projects Agency and the National Institutes of Health."