×
Biotech

Electron Microscopes Close To Imaging Individual Atoms 55

Posted by timothy from the it's-down-there-somewhere-let-me-take-another-look dept.
An anonymous reader writes with this excerpt from Science: Today's digital photos are far more vivid than just a few years ago, thanks to a steady stream of advances in optics, detectors, and software. Similar advances have also improved the ability of machines called cryo-electron microscopes (cryo-EMs) to see the Lilliputian world of atoms and molecules. Now, researchers report that they've created the highest ever resolution cryo-EM image, revealing a druglike molecule bound to its protein target at near atomic resolution. The resolution is so sharp that it rivals images produced by x-ray crystallography, long the gold standard for mapping the atomic contours of proteins. This newfound success is likely to dramatically help drugmakers design novel medicines for a wide variety of conditions.
Medicine

A Light-Powered Retina Implant For the Blind 34

Posted by Soulskill from the resistance-is-futile dept.
the_newsbeagle writes: In certain diseases of the retina, people lose function in the photoreceptor cells that respond to light and trigger a message to the brain. So engineers have designed various retina implants that do the job instead, including the Argus II system, which received the first FDA approval for an implanted visual prosthetic in 2013. But the Argus II only produces vision of about 20/1200. A new implant in the pipeline from Stanford University has already achieved 20/250 vision in rats, and is aiming at 20/120, which would be below the legal threshold for blindness. This implant is photovoltaic, so the same infrared light that beams an image of the world into the implanted chip also powers its electronics.
Medicine

Chinese Scientists Claim To Have Genetically Modified Human Embryos 182

Posted by samzenpus from the super-babies dept.
Annanag writes: There were rumours — but now it's been confirmed. Chinese scientists have attempted the ethically questionable feat of genetically modifying human embryos. The scientists try to head off ethical concerns by using 'non-viable' embryos, which cannot result in a live birth, obtained from local fertility clinics. The study is a landmark — but also a cautionary tale.
Biotech

Breakthrough In Artificial Photosynthesis Captures CO2 In Acetate 128

Posted by Soulskill from the use-it-to-3D-print-your-own-clones dept.
An anonymous reader writes: Researchers from Berkeley Lab and the U.S. Dept. of Energy have created an artificial photosynthetic process that capture carbon dioxide in acetate, "the most common building block today for biosynthesis." The research has been published in the journal Nano Letters (abstract). "Atmospheric carbon dioxide is now at its highest level in at least three million years, primarily as a result of the burning of fossil fuels. Yet fossil fuels, especially coal, will remain a significant source of energy to meet human needs for the foreseeable future. Technologies for sequestering carbon before it escapes into the atmosphere are being pursued but all require the captured carbon to be stored, a requirement that comes with its own environmental challenges. ... By combining biocompatible light-capturing nanowire arrays with select bacterial populations, the new artificial photosynthesis system offers a win/win situation for the environment: solar-powered green chemistry using sequestered carbon dioxide."
Biotech

A 2-Year-Old Has Become the Youngest Person Ever To Be Cryonically Frozen 313

Posted by Soulskill from the rest-in-peace dept.
merbs writes: After losing a long battle with brain cancer, 2-year-old Matheryn Naovaratpong became the first minor ever to be cryogenically frozen. This article is the story of how a Thai girl was frozen in Bangkok and shipped to Arizona to have her brain preserved in liquid nitrogen, while medical science works on a cure. "Typically we’d move the head from the trunk of the body. We didn't know what their reaction would be from the family, the mortuary, from border officials; this has to go through a number of shipping venues, customs, the TSA and so on. To see a frozen head in a box might have raised a number of red flags. In the U.S. that’s not a big deal, but there, they may not be accustomed."
Medicine

New Chemical Tools Lead To Targeted Cancer Drugs 21

Posted by Soulskill from the sniper-scope-built-out-of-proteins dept.
New submitter caudex writes: Proteins are encoded in DNA, and while the degeneracy of the genetic code works to minimize errors, a single DNA basepair mutation can change the structure of the encoded protein. When a mutated protein causes uncontrolled cell growth, we call it cancer. Unfortunately, proteins typically contain hundreds of amino acids, and developing a drug that will target the version of a protein containing one amino acid mutation is difficult. For this reason, most anticancer agents indiscriminately attack both mutant and healthy proteins and tissues. Researchers at Caltech have come up with a potentially general method for selectively drugging only the mutant protein at fault for cancerous activity, even in the crowded and complex milieu of living cells. Their proof of concept study published in Nature Chemistry targets the E17K mutation, which can be the causative mutation of many types of cancer.
Biotech

UW Scientists, Biotech Firm May Have Cure For Colorblindness 137

Posted by samzenpus from the greener-than-green dept.
An anonymous reader writes with news about a possible cure for colorblindness. "For the more than 10million Americans with colorblindness, there's never been a treatment, let alone a cure, for the condition that leaves them unable to distinguish certain hues. Now, for the first time, two University of Washington professors have teamed with a California biotech firm to develop what they say may be a solution: a single shot in the eye that reveals the world in full color. Jay and Maureen Neitz, husband-and-wife scientists who have studied the vision disorder for years, have arranged an exclusive license agreement between UW and Avalanche Biotechnologies of Menlo Park. Together, they've found a new way to deliver genes that can replace missing color-producing proteins in certain cells, called cones, in the eyes."
Medicine

Plaque-busting Nanoparticles Could Help Fight Tooth Decay 68

Posted by Soulskill from the reasons-to-put-nanotech-in-your-face dept.
sciencehabit writes: Nanotechnology might soon save you a trip to the dentist. Researchers have developed tiny sphere-shaped particles that ferry a payload of bacteria-slaying drugs to the surface of the teeth, where they fight plaque and tooth decay on the spot (abstract). The approach could also be adapted to combat other plaquelike substances, known as biofilms, such as those that form on medical devices like orthopedic implants.
Biotech

Biometrics Are Making Espionage Harder 104

Posted by Soulskill from the you-can-run-but-you-can't-pass-a-security-checkpoint dept.
schwit1 sends this story from Foreign Policy: In the age of iris scans and facial recognition software, biometrics experts like to point out: The eyes don't lie. And that has made tradecraft all the more difficult for U.S. spies. After billions of dollars of investment — largely by the U.S. government — the routine collection and analysis of fingerprints, iris scans, and facial images are helping to ferret out terrorists and immigration fraudsters all over the world. But it has also made it harder for undercover agents to remain anonymous.

Gone are the days of entering a country with a false passport and wearing a wig and a mustache to hide your true identity. Once an iris scan is on record, it becomes nearly impossible to evade detection. 'In the 21st century, you can't do any of that because of biometrics,' said retired Army Lt. Gen. Michael Flynn, the former director of the Defense Intelligence Agency.
Biotech

Citizen Scientists Develop Eye Drops That Provide Night Vision 81

Posted by Soulskill from the cool-toys-with-no-off-switch dept.
rtoz writes: A group of scientists in California have successfully created eye drops that temporarily enable night vision. They use mixture of insulin and a chemical known as Chlorin e6 (Ce6) to enable the user to view objects clearly in darkness up to 50 meters away. Ce6 is found in some deep-sea fish and often used to treat night blindness. The solution starts to work within an hour of being applied to the user's eyes, and lasts for several hours afterward. The test subject's eyesight returned to normal the next day. The organization Science for the Masses has released a paper detailing the experiment on their website.
Biotech

Robobug: Scientists Clad Bacterium With Graphene To Make a Working Cytobot 41

Posted by samzenpus from the cyborg-virus dept.
Zothecula writes By cladding a living cell with graphene quantum dots, researchers at the University of Illinois at Chicago (UIC) claim to have created a nanoscale biomicrorobot (or cytobot) that responds electrically to changes in its environment. This work promises to lay the foundations for future generations of bio-derived nanobots, biomicrorobotic-mechanisms, and micromechanical actuation for a wide range of applications. "UIC researchers created an electromechanical device — a humidity sensor — on a bacterial spore. They call it NERD, for Nano-Electro-Robotic Device. The report is online at Scientific Reports, a Nature open access journal."
Biotech

The One Thousand Genes You Could Live Without 111

Posted by samzenpus from the stuff-you-don't-need dept.
sciencehabit writes Today researchers unveiled the largest ever set of full genomes from a single population: Iceland. The massive project, carried out by a private company in the country, deCODE genetics, has yielded new disease risk genes, insights into human evolution, and a list of more than 1000 genes that people can apparently live without. The project also serves as a model for other countries' efforts to sequence their people's DNA for research on personalized medical care, says study leader Kári Stefánsson, deCODE's CEO. For example, the United States is planning to sequence the genomes of 1 million Americans over the next few years and use the data to devise individualized treatments.
Australia

Draconian Australian Research Law Hits Scientists 150

Posted by Soulskill from the blunder-down-under dept.
An anonymous reader writes: The Australian government is pushing ahead with a draconian law placing "dual use" science (e.g. encryption, biotechnology) under the control of the Department of Defence. The Australian ACLU, Civil Liberties Australia, warns the law punishes scientists with $400,000 fines, 10 years in jail and forfeiture of their work, just for sending an "inappropriate" e-mail.

Scientists — including the academics union — warn the laws are unworkable despite attempted improvements, and will drive researchers offshore (paywalled: mirror here).
Biotech

Scientists: It's Time To Resolve the Ethics of Editing Human Genome 299

Posted by Soulskill from the but-we-haven't-created-a-real-spiderman-yet dept.
An anonymous reader writes: We've previously discussed a system called CRISPR-cas9, which is dramatically reducing the cost and effort required to do gene editing. In fact, the barrier to entry is now so low that a group of biologists is calling for a moratorium on using the method to modify the human genome. Writing in the journal Science (abstract), the scientists warn that we've reached the point where the ethical questions surrounding DNA alteration can be put off no longer. David Baltimore, one of the group's members, said, "You could exert control over human heredity with this technique, and that is why we are raising the issue. ... I personally think we are just not smart enough — and won't be for a very long time — to feel comfortable about the consequences of changing heredity, even in a single individual." Another group of scientists called for a similar halt to human germline modification, and the International Society for Stem Cell Research says it agrees.
Biotech

Sloppy Biosafety Procedures Found At Federal Disease Center 21

Posted by Soulskill from the what-could-possibly-go-wrong dept.
schwit1 writes: An investigation of a federal center for studying dangerous diseases in primates has found serious biosafety procedure violations. "Concerns arose at the center in Covington, Louisiana, after two rhesus macaques became ill in late November with melioidosis, a disease caused by the tropical bacterium Burkholderia pseudomallei. In January, the U.S. Centers for Disease Control and Prevention (CDC) and Department of Agriculture investigators traced the strain infecting the primates to a vaccine research lab working with mice. Last month, as the investigation continued, CDC suspended the primate center's 10 or so research projects involving B. pseudomallei and other select agents (a list of dangerous bacteria, viruses, and toxins that are tightly regulated). Meanwhile, a report in USA Today suggested the bacterium might have contaminated the center's soil or water. In addition, workers "frequently entered the select agent lab without appropriate protective clothing," the release says. No center staff has shown signs of illness. On 12 March, however, Tulane announced that blood tests have found that one worker has low levels of antibodies to the bacterium, suggesting possible exposure at the center, according to ABC News."
Biotech

Lawsuit Over Quarter Horse's Clone May Redefine Animal Breeding 172

Posted by Soulskill from the reasons-genetic-superhorses-will-take-over-the-world dept.
schwit1 sends this report from the LA Times: "Lynx Melody Too, a clone of a renowned quarter horse, is at the center of a lawsuit that could change the world of animal breeding and competition. Texas horse breeder Jason Abraham and veterinarian Gregg Veneklasen sued the American Quarter Horse Assn., claiming that Lynx Melody Too should be allowed to register as an official quarter horse. A Texas jury decided in their favor in 2013, but a three-judge panel of the U.S. 5th Circuit Court of Appeals reversed that ruling in January, saying there was 'insufficient' evidence of wrongdoing by the association.

The suit is among the first to deal with the status of clones in breeding and competition, and its outcome could impact a number of fields, including thoroughbred horse racing and dog breeding. The quarter horse association is adamant that clones and their offspring have no place in its registry. "It's what AQHA was founded on — tracking and preserving the pedigrees of these American quarter horses," said Tom Persechino, executive director of marketing for the association. "When a person buys an American quarter horse, they want to know that my quarter horse has the blood of these horses running through it, not copies of it."
Biotech

Controlling Brain Activity With Magnetic Nanoparticles 42

Posted by Soulskill from the i-saw-that-episode-of-star-trek-too dept.
sciencehabit writes: Deep brain stimulation, which now involves surgically inserting electrodes several inches into a person's brain and connecting them to a power source outside the skull, can be an extremely effective treatment for disorders such as Parkinson's disease, obsessive compulsive disorder, and depression. The expensive, invasive procedure doesn't always work, however, and can be risky. Now, a study in mice (abstract) points to a less invasive way to massage neuronal activity, by injecting metal nanoparticles into the brain and controlling them with magnetic fields. The technique could eventually provide a wireless, nonsurgical alternative to traditional deep brain stimulation surgery, researchers say.
Biotech

New Molecular 3D Printer Can Create Billions of Compounds 132

Posted by Soulskill from the go-big-or-go-home dept.
ErnieKey writes: University of Illinois researchers have created a device, called a Molecular-Machine, which essentially manufactures on the molecular compound level. Martin Burke, the lead researcher on this project says that they are already able to synthesize over a billion different compounds with the machine, compounds which up until now have been very difficult to synthesize. The impact on the pharmaceutical industry could be staggering.
Biotech

The Origin of Life and the Hidden Role of Quantum Criticality 188

Posted by timothy from the tasers-hurt-us-at-a-deep-level dept.
KentuckyFC writes One of the great puzzles of biology is how the molecular machinery of life is so finely coordinated. Even the simplest cells are complex three dimensional biochemical factories in which a dazzling array of machines pump, push, copy, and compute in a dance of extraordinarily detailed complexity. Indeed, it is hard to imagine how the ordinary processes of electron transport allow this complexity to emerge given the losses that arise in much simpler circuits. Now a group of researchers led by Stuart Kauffmann have discovered that the electronic properties of biomolecules are entirely different to those of ordinary conductors. It turns out that most biomolecules exist in an exotic state called quantum criticality that sits on the knife edge between conduction and insulation. In other words, biomolecules belong to an entirely new class of conductor that is not bound by the ordinary rules of electron transport. Of course, organic molecules can be ordinary conductors or insulators and the team have found a few biomolecules that fall into these categories. But evolution seems to have mainly selected biomolecules that are quantum critical, implying that that this property must confer some evolutionary advantage. Exactly what this could be isn't yet clear but it must play an important role in the machinery of life and its origin.
Biotech

Inside the Weird World of 3D Printed Body Parts 61

Posted by samzenpus from the pick-a-spleen-any-spleen dept.
An anonymous reader writes Last November a news report in Russia Today sent a shudder of excitement through the tech blogs that cover 3D printing: an eccentric Russian provocateur claimed he would this month start printing functioning thyroids. Tech reporter Andrew Leonard set out to fact-check that claim, and along the way discovered an unlikely relationship between a Russian mad scientist and the U.S.'s most advanced, most respected 3d bioprinting companies—TeVido, which aims to 3D print custom nipples, and Organovo, which sells samples of 3D printed liver tissue. In the field of 3D printing, the line between science fiction and peer-reviewed research is very, very thin.

Slashdot Top Deals