An anonymous reader writes: Google's London-based AI group DeepMind has launched DeepMind Health, teaming up with the NHS to work on its first project. The "neuroscience-inspired" company, bought by Google in 2014, said of the collaboration: "We want to see the NHS thrive, and to ensure that its talented clinicians get the tools and support they need to continue providing world-class care." In its first initiative alongside kidney experts at London's Royal Free Hospital, DeepMind Health has introduced a mobile app called Streams. The software is designed to support the provision of critical information to doctors and nurses in order to help detect the presence of acute kidney injuries (AKI). To support the development of the Streams app, the AI group has also acquired clinical task management app company Hark.

ffkom writes: A recent publication from German researchers claims success in removing the HI-Virus from living cells, showing a way to completely cure AIDS rather than just suppressing its symptoms (by lowering the amount of viruses) by permanent medication: "Current combination antiretroviral therapies (cART) efficiently suppress HIV-1 reproduction in humans, but the virus persists as integrated proviral reservoirs in small numbers of cells. To generate an antiviral agent capable of eradicating the provirus from infected cells, we employed 145 cycles of substrate-linked directed evolution to evolve a recombinase (Brec1) that site-specifically recognizes a 34-bp sequence present in the long terminal repeats (LTRs) of the majority of the clinically relevant HIV-1 strains and subtypes. Brec1 efficiently, precisely and safely removes the integrated provirus from infected cells and is efficacious on clinical HIV-1 isolates in vitro and in vivo, including in mice humanized with patient-derived cells. Our data suggest that Brec1 has potential for clinical application as a curative HIV-1 therapy." Clinical trials are expected to start in Hamburg, Germany, soon.

hypnosec writes: Researchers have revealed through a new study that fungi from the gut of herbivores like goats, horses and sheep could be used to make biofuel. According to researchers at University of California, Santa Barbara, the fungi retrieved from these animals are capable of converting plant material into sugars that can be easily used to make biofuel and other products at the same efficiency as the best fungi engineering in the industry. Michelle O'Malley, lead author of the paper and professor of chemical engineering at the University, explains that these fungi naturally have the best possible set of enzymes for the job of breaking down biomass and as per their findings, these enzymes work together to break down stubborn plant material.

Zothecula writes: 3D printed tissues and organs have shown real potential in addressing shortages of available donor tissue for people in need of transplants, but having them take root and survive after implantation has proven difficult to achieve. In a positive move for the technology, researchers used a newly-developed 3D printer to produce human-scale muscle structures that matured into functional tissue after being implanted into animals.

gthuang88 writes: Environmental factors like temperature, humidity, or lighting often derail life science experiments. Now Elemental Machines, a startup from the founders of Misfit Wearables, is trying to help scientists debug experiments using distributed sensors and machine-learning software to detect anomalies. The product is in beta testing with academic labs and biotech companies. The goal is to help speed up things like biology research and drug development. Wiring up experiments is part of a broader effort to create "smart labs" that automate some of the scientific process.

sciencehabit writes: Researchers have engineered tiny gold particles that can assemble into a variety of crystalline structures simply by adding a bit of DNA to the solution that surrounds them. Down the road, such reprogrammable particles could be used to make materials that reshape themselves in response to light, or to create novel catalysts that reshape themselves as reactions proceed.

sciencehabit writes: An experimental assisted reproduction technique that could allow some families to avoid having children with certain types of heritable disease should be allowed to go forward in the United States, provided it proceeds slowly and cautiously. That is the conclusion of a report released today from a panel organized by the U.S. National Academies of Sciences, Engineering, and Medicine (NAS), which assesses the ethics questions surrounding the controversial technique called mitochondrial DNA replacement therapy. More controversially, however, the panel recommended that only altered male embryos should be used to attempt a pregnancy, to limit the possible risks to future generations. (Males can't pass along the mitochondrial DNA that is altered in the procedure.)

sciencehabit writes: Developmental biologist Kathy Niakan has received permission from U.K. authorities to modify human embryos using the CRISPR/Cas9 gene-editing technology. Niakan, who works at the Francis Crick Institute in London, applied for permission to use the technique in studies to better understand the role of key genes during the first few days of human embryo development.

The Human Fertilisation and Embryology Authority (HFEA), which grants licenses for work with human embryos, sperm, and eggs in the United Kingdom, approved Niakan's application at a meeting of HFEA's license committee on 14 January. The minutes of that meeting state that, '[o]n balance, the proposed use of CRISPR/Cas9 was considered by the Committee to offer better potential for success, and was a justified technical approach to obtaining research data about gene function from the embryos used.'

hypnosec writes: In what has been claimed to be the first use of gene editing technique CRISPR for replacement of a defective gene associated with a sensory disease, researchers have repaired a genetic defect that causes blindness. The research that led to successful editing of defective genes responsible for retinitis pigmentosa (RP) – an inherited condition that causes the retina to degrade and leads to blindness in at least 1.5 million cases worldwide – was carried out using stem cells derived from a patient's tissue. Published in Scientific Reports, the study paves the way for using CRIPSR therapeutically to treat eye diseases.

An anonymous reader writes: 2016 has not started well for blood-testing startup Theranos. Already facing allegations of data manipulation, the Centers for Medicare and Medicaid Services have found problems with Theranos' laboratory in Newark, California, putting the company's relationship with the Medicare program in danger. WSJ reports: "It isn't clear exactly what regulators have faulted Theranos for in their latest inspection, which took several months. Adverse findings would be another regulatory setback for one of Silicon Valley's highest-profile startups, valued at about $9 billion in 2014. Theranos already has stopped collecting tiny samples of blood from patients' fingers for all but one of its tests while it waits for the Food and Drug Administration to review the company's applications for wider use of the proprietary vials called 'nanotainers.' In October, the FDA said it had determined that the nanotainers were an 'uncleared medical device.'"

An anonymous reader writes: Three science papers that had suggested that genetically modified crops were harmful to animals and have been used by activist groups to argue for their ban have been found to contain manipulated and possibly falsified data. Nature reports: "Papers that describe harmful effects to animals fed genetically modified (GM) crops are under scrutiny for alleged data manipulation. The leaked findings of an ongoing investigation at the University of Naples in Italy suggest that images in the papers may have been intentionally altered. The leader of the lab that carried out the work there says that there is no substance to this claim. The papers' findings run counter to those of numerous safety tests carried out by food and drug agencies around the world, which indicate that there are no dangers associated with eating GM food. But the work has been widely cited on anti-GM websites — and results of the experiments that the papers describe were referenced in an Italian Senate hearing last July on whether the country should allow cultivation of safety-approved GM crops. 'The case is very important also because these papers have been used politically in the debate on GM crops,' says Italian senator Elena Cattaneo, a neuroscientist at the University of Milan whose concerns about the work triggered the investigation.

An anonymous reader writes: Silicon-based electronic circuits that operate flawlessly in the body for some number of days--soon weeks--and then harmlessly dissolve: they're what University of Illinois professor John Rogers says is the next frontier of electronics. Today he released news of successful animal tests on such transient electronics designed for use in brain implants, but says they could be used just about anywhere in the body. As these devices move into larger animal and eventually human tests, Rogers says he'll be working on the next generation--devices that intervene to accelerate healing or manage medical conditions, not just monitor them.

Zane C. writes: The 100,000 Genomes project, an organization dedicated to diagnosing and researching rare genetic disorders, has just diagnosed its first 2 patients. After painstakingly analyzing about 3 billion base pairs from the parents of one young girl, and the girl herself, "doctors told them the genetic abnormality — in a gene called KDM5b — had been identified". The new information will not yet change the way the young girl, named Georgia, is treated, but it opens up a path for future treatments. For the other girl, Jessica, the genetic analysis provided enough information to diagnose and begin a new treatment. A mutation had occurred "[causing] a condition called Glut1 deficiency syndrome in which the brain cannot get enough energy to function properly." Jessica's brain specifically had not been able to obtain enough sugar to power her brain cells, and as such, doctors prescribed a high fat diet to give her brain an alternate energy source. She has already begun showing improvement.

hypnosec writes: In a first kind of discovery in decades, researchers have created a new class of hybrid sound waves that are gentle enough to be used in biomedical devices. Known as "surface reflected bulk waves", the new class of sound waves are a hybrid of bulk waves and surface waves and have been created by a team at RMIT University in Melbourne, Australia. According to the team the new class of sound waves have already proved their worth in delivering vaccines and other drugs directly to the lung and are hopeful that their creation could lead to a revolution in stem cell therapy. As Dr Amgad Rezk, from RMIT's Micro/Nano Research Laboratory, explains, they have already dramatically improved the efficiency of an innovative new "nebuliser" that could deliver vaccines and other drugs directly to the lung in as little as 30 seconds [study abstract]. Researchers are hopeful that their work opens up the possibility of using stem cells more efficiently for treating lung disease enabling them to nebulise stem cells straight into a specific site within the lung to repair damaged tissue and this could be a real game changer for stem cell treatment in lungs as well as other organs.

Press2ToContinue writes: A German carpenter has invented a valve which he claims will revolutionize contraception, by allowing a man to turn the flow of sperm from his testicles on and off at the flick of a switch. It (the switch, of course) is nearly an inch long and weighs less than a tenth of an ounce. It is surgically implanted on the vas deferens, the tube that carries sperm from the testicles, in a half-hour operation, and controlled by a switch beneath the skin of the scrotum.

So far Bimek is the only man who has the switches implanted, one for each testicle. I wonder what other switches we will see implanted into humans in the future? I think I'd like a valve for adrenaline control.

the_newsbeagle writes: Now that it's easy and cheap to build strands of DNA, what kinds of strange new organisms will scientists and start-ups build? That's the question raised as synthetic biology companies like Twist Bioscience and Zymergen start up their DNA manufacturing lines. Researchers who order DNA snippets typically pay on a cost-per-nucleobase basis. These companies say their mass-production techniques could bring prices down to 2 cents per base, which would allow researchers to scale up experiments and learn through trial and error.

schwit1 writes with news that scientists have used a new gene-editing technique called CRISPR to treat mice with defective dystrophin genes. This is the first time that such a method has successfully treated a genetic disease inside a living mammal. The Times reports: "Three research groups, working independently of one another, reported in the journal Science that they had used the Crispr-Cas9 technique to treat mice with a defective dystrophin gene. Each group loaded the DNA-cutting system onto a virus that infected the mice's muscle cells, and excised from the gene a defective stretch of DNA known as an exon. Without the defective exon, the muscle cells made a shortened dystrophin protein that was nonetheless functional, giving all of the mice more strength."

An anonymous reader writes: A lengthy report at the Wall Street Journal brings allegations of data manipulation against blood-testing startup Theranos. The company raised hundreds of millions of dollars from investors, at a valuation of roughly $9 billion, on the hope that they can revolutionize medical diagnosis. They've also made agreements with Safeway and Walgreen's to offer blood tests within stores. But multiple former employees say Theranos was shaky on the science at best, and intentionally misrepresentative at worst.

Engineer Anthony Nugent says the device intended for Walgreen's was still experimental. He also recalls seeing the machines labeled "for investigational use only," because of poor accuracy. A Theranos lab worker "told federal authorities that the results from the quality-control runs diverged from the known amount by more than two standard deviations, a red flag that suggested possible accuracy problems." When that employee notified superiors within the company, somebody came and deleted the quality control data, which made the device's test runs appear better than they were. There are also reports that inspectors and auditors were purposefully kept away from parts of Theranos's lab. A Theranos spokesperson denied everything.

Press2ToContinue writes with this profile of Anatoli Brouchkov, a scientist who isn't afraid to take an extremely hands-on approach to science. Vice reports: "Anatoli Brouchkov is a soft-spoken guy with silver hair, and when he lets out a reserved chuckle, his eyes light up like he was belly laughing. If you met him on the street, you'd never guess that he once injected himself with a 3.5 million-year-old strain of bacteria, just to see what would happen. According to Brouchkov, Bacillus F has a mechanism that has enabled it to survive for so long beneath the ice, and that the same mechanism could be used to extend human life, too—perhaps, one day, forever. In tests, Brouchkov says the bacteria allowed female mice to reproduce at ages far older than typical mice. Fruit flies, he told the Siberian Times, also experienced a 'positive impact' from exposure to the bacteria."

neoritter writes: The issues of reproducibility in journals continues to present problems. This time in the world of clinical geneticists where a misleading or incorrect journal on the effect of a gene variant can affect the decisions made by doctors and patients alike; from heart monitoring implants to abortions. Poor sampling and low thresholds for evidence have led some clinical geneticists to work towards an open database of genetic information. Scientists and doctors would go to a "one-stop shop for disease genes" to check and share information with each other under the strictest of standards.